systemic

adj

1. (not-comparable)Embedded within and spread throughout and affecting a whole system, group, body, economy, market, or society.

   “We can learn from the incidents found it the project database - looking at them and understanding what happened and what might have been done differently. We can see past errors, including systemic issues that required attention at managerial levels.”

2. (not-comparable)Pertaining to an entire organism.

   “Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE).”